DADLE - Misplaced Pages

Synthetic opioid analgesic peptide

DADLE
Names

IUPAC name (2R)-2-amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
Other names • -Enkephalin • L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-Leucine • N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-D-Leucine • Tyr-D-Ala-Gly-Phe-D-Leu-OH
Identifiers
CAS Number	63631-40-3
3D model (JSmol)	Interactive image
ChemSpider	5292936
ECHA InfoCard	100.059.337
PubChem CID	6917707
UNII	HB4QD9GL6F
InChI InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1Key: ZHUJMSMQIPIPTF-IBURTVSXSA-N InChI=1/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1Key: ZHUJMSMQIPIPTF-IBURTVSXBS
SMILES N(C(N(C)C(NCC(N(CC1=CC=CC=C1)C(N(CC(C)C)C(O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2
Properties
Chemical formula	C₂₉H₃₉N₅O₇
Molar mass	569.659 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is ?) Infobox references

Chemical compound

DADLE (-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective δ-opioid receptor agonist, it also binds to the μ₁ subtype of μ-opioid receptors.

Treatment with DADLE results in transient depression of mean arterial blood pressure and heart rate.

Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.