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A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments. Many topical medications are epicutaneous, meaning that they are applied directly to the skin. Topical medications may also be inhalational, such as asthma medications, or applied to the surface of tissues other than the skin, such as eye drops applied to the conjunctiva, or ear drops placed in the ear, or medications applied to the surface of a tooth. The word topical derives from Greek τοπικός topikos, "of a place".

Justification

Topical drug delivery is a route of administering drugs via the skin to provide topical therapeutic effects. As skin is one of the largest and most superficial organs in the human body, pharmacists utilise it to deliver various drugs. This system usually provides a local effect on certain positions of the body. In ancient times, people used herbs to put on wounds for relieving the inflammatory effect or as pain relievers. The use of topical drug delivery system is much broader now, from smoking cessation to beauty purposes. Nowadays, there are numerous dosage forms that can be used topically, including cream, ointment, lotion, patches, dusting powder and much more. There are many advantages for this drug delivery system – avoiding first pass metabolism which can increase its bioavailability, being convenient and easy to apply to a large area, being easy to terminate the medication and avoiding gastro-intestinal irritations. All these can increase the patient compliance. However, there are several disadvantages for this system – causing skin irritations and symptoms like rashes and itchiness may occur. Also, only small particles can pass through the skin, which limits the choice of drugs. Since skin is the main medium of topical drug delivery system, its conditions determine the rate of skin penetration leading to affecting the pharmacokinetics of the drug. The temperature, pH value and dryness of the skin need to be considered. There are some novel topical drugs in the market which can utilise the system as much as possible.

This localized system provides topical therapeutic effects via skin, eyes, nose and vagina to treat diseases. The most common usage is for local skin infection problems. Dermatological products have various formulations and range in consistency though the most popular dermal products are semisolid dosage forms to provide topical treatment.

Factor affecting topical drug absorption

Topical drug absorption depends on two major factors – biological and physicochemical properties.

The first factor concerns body structure effects on the drugs. The degradation of drugs can be affected by the site of applications. Some studies discovered different Percutaneous absorption patterns. Apart from the place, age also affects the absorption as the skin structure changes with age. The lowered collagen and broadened blood capillary networks happen with ageing. These features alter the effectiveness of absorption of both hydrophilic and lipophilic substances into stratum corneum underneath the surface of skin. The skin surface integrity can also affect the permeability of drugs such as the density of hair follicles, sweat glands or disintegrated by inflammation or dehydration.

The other factor concerns metabolism of medications on skin. When the percutaneous drug is applied on skin, it will be gradually absorbed down the skin. Normally, when the drugs are absorbed, they will be metabolised by various enzymes in our body and the amount will be lower. The exact amount delivered to the target action site determines the potency and bioavailability of the drugs. If the concentration is too low, the therapeutic effect is impeded; if the concentration is too high, drug toxicity may happen to cause side effects or even do harm to our body. For the topical drug delivery way, degradation of drugs in skin is very low compared to liver. The metabolism of drugs is mainly by metabolic enzyme cytochrome P450, and this enzyme is not active in skin. The CYP450 actively metabolized drugs can then maintain high concentration when being applied on skin. Despite CYP450 enzyme action, the partition coefficient (K) determines the activity of topical drugs. The ability of drug particles to go through the skin layer also affects the absorption of drugs. For transdermal activity, medicines with higher K value are harder to get rid of the lipid layer of skin cells. The trapped molecules then cannot penetrate into the skin. This reduces the efficacy of the transdermal drugs. The drugs target cells underneath the skin or need to diffuse into blood capillary to exert their effect. Meanwhile, the size of particles affects this transdermal process. The smaller the drug molecules, the faster the rate of penetration. Polarity of the drugs can affect this diffusion rate too. If the drug shows lower degree of ionization, it is less polar. Therefore, it can have a faster absorption rate.

Local versus systemic effect

The definition of the topical route of administration sometimes states that both the application location and the pharmacodynamic effect thereof is local.

In other cases, topical is defined as applied to a localized area of the body or to the surface of a body part regardless of the location of the effect. By this definition, topical administration also includes transdermal application, where the substance is administered onto the skin but is absorbed into the body to attain systemic distribution. Such medications are generally hydrophobic chemicals, such as steroid hormones. Specific types include transdermal patches which have become a popular means of administering some drugs for birth control, hormone replacement therapy, and prevention of motion sickness. One example of an antibiotic that may be applied topically is chloramphenicol.

If defined strictly as having a local effect, the topical route of administration can also include enteral administration of medications that are poorly absorbable by the gastrointestinal tract. One poorly absorbable antibiotic is vancomycin, which is recommended by mouth as a treatment for severe Clostridioides difficile colitis.

Choice of base formulation

A medication's potency often is changed with its base. For example, some topical steroids will be classified one or two strengths higher when moving from cream to ointment. As a rule of thumb, an ointment base is more occlusive and will drive the medication into the skin more rapidly than a solution or cream base.

The manufacturer of each topical product has total control over the content of the base of a medication. Although containing the same active ingredients, one manufacturer's cream might be more acidic than the next, which could cause skin irritation or change its absorption rate. For example, a vaginal formulation of miconazole antifungal cream might irritate the skin less than an athlete's foot formulation of miconazole cream. These variations can, on occasion, result in different clinical outcomes, even though the active ingredient is the same. No comparative potency labeling exists to ensure equal efficacy between brands of topical steroids (percentage of oil vs water dramatically affect the potency of topical steroid). Studies have confirmed that the potency of some topical steroid products may differ according to manufacturer or brand. An example of this is the case of brand name Valisone cream and Kenalog cream in clinical studies have demonstrated significantly better vasoconstrictions than some forms of this drug produced by generic drug manufacturers. However, in a simple base like an ointment, much less variation between manufacturers is common.

In dermatology, the base of a topical medication is often as important as the medication itself. It is extremely important to receive a medication in the correct base, before applying to the skin. A pharmacist should not substitute an ointment for a cream, or vice versa, as the potency of the medication can change. Some physicians use a thick ointment to replace the waterproof barrier of the inflamed skin in the treatment of eczema, and a cream might not accomplish the same clinical intention.

Formulations

There are many general classes, with no clear dividing line among similar formulations. As a result, what the manufacturer's marketing department chooses to list on the label of a topical medication might be completely different from what the form would normally be called.

Cream

A cream is an emulsion of oil and water in approximately equal proportions. It penetrates the stratum corneum outer layer of skin wall. Cream is thicker than lotion, and maintains its shape when removed from its container. It tends to be moderate in moisturizing tendency. For topical steroid products, oil-in-water emulsions are common. Creams have a significant risk of causing immunological sensitization due to preservatives and have a high rate of acceptance by patients. There is a great variation in ingredients, composition, pH, and tolerance among generic brands.

Foam

Topical corticosteroid foams are suitable for treating a range of skin conditions that respond to corticosteroids. These foams are typically simple to apply, which can lead to better patient compliance and, in turn, improve treatment results for those who favor a more convenient and cleaner topical option. Foam can be typically seen with topical steroids marketed for the scalp.

Gel

Gels are thicker than liquids. Gels are often a semisolid emulsion and sometimes use alcohol as a solvent for the active ingredient; some gels liquefy at body temperature. Gel tends to be cellulose cut with alcohol or acetone. Gels tend to be self-drying, tend to have greatly variable ingredients between brands, and carry a significant risk of inducing hypersensitivity due to fragrances and preservatives. Gel is useful for hairy areas and body folds. In applying gel one should avoid fissures in the skin, due to the stinging effect of the alcohol base. Gel enjoys a high rate of acceptance due to its cosmetic elegance.

Lotion

Lotions are similar to solution but are thicker and tend to be more emollient in nature than solution. They are usually oil mixed with water, and more often than not have less alcohol than solution. Lotions can be drying if they contain a high amount of alcohol.

Ointment

An ointment is a homogeneous, viscous, semi-solid preparation; most commonly a greasy, thick water-in-oil emulsion (80% oil, 20% water) having a high viscosity, that is intended for external application to the skin or mucous membranes. Ointments have a water number that defines the maximum amount of water that they can contain. They are used as emollients or for the application of active ingredients to the skin for protective, therapeutic, or prophylactic purposes and where a degree of occlusion is desired.

Ointments are used topically on a variety of body surfaces. These include the skin and the mucous membranes of the eye (an eye ointment), chest, vulva, anus, and nose. An ointment may or may not be medicated.

Ointments are usually very moisturizing, and good for dry skin. They have a low risk of sensitization due to having few ingredients beyond the base oil or fat, and low irritation risk. There is typically little variability between brands of drugs. They are often disliked by patients due to greasiness.

The vehicle of an ointment is known as the ointment base. The choice of a base depends upon the clinical indication for the ointment. The different types of ointment bases are:

• Absorption bases, e.g., beeswax and wool fat
• Emulsifying bases, e.g., cetrimide and emulsifying wax
• Hydrocarbon bases, e.g., ceresine, microcrystalline wax, hard paraffin, and soft paraffin
• Vegetable oil bases, e.g., almond oil, coconut oil, olive oil, peanut oil, and sesame oil
• Water-soluble bases, e.g., macrogols 200, 300, 400

The medicaments are dispersed in the base and are divided after penetrating the living cells of the skin.

The water number of an ointment is the maximum quantity of water that 100g of a base can contain at 20 °C.

Ointments are formulated using hydrophobic, hydrophilic, or water-emulsifying bases to provide preparations that are immiscible, miscible, or emulsifiable with skin secretions. They can also be derived from hydrocarbon (fatty), absorption, water-removable, or water-soluble bases.

Evaluation of ointments:

1. Drug content
2. Release of medicament from base
3. Medicament penetration
4. Consistency of the preparation
5. Absorption of medicament into blood stream
6. Irritant effect

Properties which affect choice of an ointment base are:

1. Stability
2. Penetrability
3. Solvent property
4. Irritant effects
5. Ease of application and removal

Methods of preparation of ointments:

• Fusion: In this method the ingredients are melted together in descending order of their melting points and stirred to ensure homogeneity.
• Trituration: In this finely subdivided insoluble medicaments are evenly distributed by grinding with a small amount of the base followed by dilution with gradually increasing amounts of the base.

Paste

Paste combines three agents – oil, water, and powder. It is an ointment in which a powder is suspended.

Powder

Powder is either the pure drug by itself (talcum powder), or is made of the drug mixed in a carrier such as corn starch or corn cob powder (Zeosorb AF – miconazole powder). Can be used as an inhaled topical (cocaine powder used in nasal surgery).

Shake lotion

A shake lotion is a mixture that separates into two or three parts over time. Frequently, an oil mixed with a water-based solution needs to be shaken into suspension before use and includes the instructions: "Shake well before use".

Solid

Medication may be placed in a solid form. Examples are deodorant, antiperspirants, astringents, and hemostatic agents. Some solids melt when they reach body temperature (e.g. rectal suppositories).

Sponge

Certain contraceptive methods rely on sponge as a carrier of a liquid medicine. Lemon juice embedded in a sponge has been used as a primitive contraception in some cultures.

Tape

Cordran tape is an example of a topical steroid applied under occlusion by tape. This greatly increases the potency and absorption of the topical steroid and is used to treat inflammatory skin diseases.

Tincture

A tincture is a skin preparation that has a high percentage of alcohol. It would normally be used as a drug vehicle if drying of the area is desired.

Topical solution

Topical solutions can be marketed as drops, rinses, or sprays, are generally of low viscosity, and often use alcohol or water in the base. These are usually a powder dissolved in alcohol, water, and sometimes oil; although a solution that uses alcohol as a base ingredient, as in topical steroids, can cause drying of the skin. There is significant variability among brands, and some solutions may cause irritation, depending on the preservative(s) and fragrances used in the base.

Some examples of topical solutions are given below:

1. Aluminium acetate topical solution: This is colorless, with a faint acetous odour and sweetish taste. It is applied topically as an astringent after dilution with 10-40 parts of water. This is used in many types of dermatologic creams, lotions, and pastes. Commercial premeasured and packed tablets and powders are available for this preparation.
2. Povidone iodine topical solution: This is a chemical complex of iodine with polyvinylpyrrolidone. The agent is a polymer with an average molecular weight of 40,000. The povidone iodine contains 10% available iodine, slowly released when applied to skin. This preparation is employed topically as a surgical scrub and non irritating antiseptic solution; its effectiveness is directly attributed to the presence and release of iodine from the complex. Commercial product: Betadine solution.

Transdermal patch

Transdermal patches can be a very precise time released method of delivering a drug. Cutting a patch in half might affect the dose delivered. The release of the active component from a transdermal delivery system (patch) may be controlled by diffusion through the adhesive which covers the whole patch, by diffusion through a membrane which may only have adhesive on the patch rim or drug release may be controlled by release from a polymer matrix. Cutting a patch might cause rapid dehydration of the base of the medicine and affect the rate of diffusion.

Vapor

Some medications are applied as an ointment or gel, and reach the mucous membrane via vaporization. Examples are nasal topical decongestants and smelling salt.

Topical Drug Classification System (TCS)

Topical drug classification system (TCS) is proposed by the FDA. It is designed from the Biopharmaceutics Classification System (BCS) for oral immediate release solid drug products which is very successful for decades. There are 3 aspects to assess and 4 classes in total. The 3 aspects include qualitative (Q1), quantitative (Q2) and similarity of in vitro release (IVR) rate (Q3).

Advantages of topical drug delivery systems

In the early 1970s, the Alza Corporation, through their founder Alejandro Zaffaroni, filed the first US patents describing transdermal delivery systems for scopolamine, nitroglycerin and nicotine. People found that applying medicines on the body surfaces is beneficial in many aspects. Skin medicines can give faster onset and local effect on our body as the surface cream can bypass first pass metabolism such as hepatic and intestinal metabolism. Apart from the absorption, dermal drugs effectively prevent oral delivery limitations such as nausea and vomiting and poor appliances due to unpalatable tastes of the drugs . Topical application is an easy way for patients to tackle skin infections in a painless and non-invasive way. From a patient perspective, applying drugs on skin also provides stable dosage in blood so as to give the optimal bioavailability and therapeutic effects. In case of overdose or unwanted side effects, patients can take off or wash out the medicines quickly to eliminate toxicity by simply removing the patch to stop the delivery of drugs.

Disadvantages of topical drug delivery systems

The site of putting the patches for topical drugs may get irritated and have rashes and feel itchy. Hence, some topical drugs including nicotine patches for smoking cessation are advised to change places for each application to avoid continuous irritation of the skin. Also, since the drug needs to penetrate the skin, some drugs may not be able to pass through the skin. Some drugs are then “wasted” and the bioavailability of the drug will decrease.

Challenges for designing topical dosage form

Skin penetration is the main challenge for any topical dosage form. The drug needs to penetrate the skin in order to get into the body to apply its function. The drug follows the Fick's first law of diffusion. One of the most common versions of Fick's first law of diffusion is:

${\displaystyle J=-D{dc \over dx}}$

where

• J is the diffusion flux.
• D is the diffusion coefficient.
• dc/dx is the concentration gradient.

For D is described by the Stokes–Einstein equation. The equation is:

${\displaystyle D={\frac {RT}{6\pi \eta rN_{A}}}}$

where

• R is the gas constant.
• T is the temperature.
• η is the viscosity.
• r is the radius of the solute.
• ${\displaystyle N_{A}}$ is the Avogadro constant.

Assuming concentration gradient is constant for all newly applied topical drugs and the temperature is constant (normal body temperature: 37 °C), the viscosity and radius of the drug determine the flux of diffusion. The higher the viscosity or the larger the radius of the drug is, the lower the diffusion flux of the drug is.

New developments

There are many factors for drug developers to consider in developing new topical formulations.

The first one is the effect of the drug vehicle. The medium to carry the topical drugs can affect the penetration of the drug active ingredient and efficacy. For example, this carrier can have a cooling, drying, emollient or protective action to suit the required conditions of the application site such as applying gel or lotion for hairy areas. Meanwhile, scientists need to match the type of preparation with the type of lesions. For example, they need to avoid oily ointments for acute weepy dermatitis. Chemists also need to consider the irritation or any sensitization potential to ensure that the topical application can be stable during storage and transport to maintain its efficacy. Another potential material is nanofiber-based dispersion to improve the adhesion of active ingredients on the skin.

In order to enhance drug penetration into the skin, scientists have several ways to achieve their purposes by using chemical, biochemical, physical and super saturation enhancement. Advanced Emulgel technology is a breakthrough of painkilling topical drugs. It helps the gel to enter deeply down the skin layer to strengthen delivery of diclofenac to the point of pain so as to achieve better therapeutic effects by modifying the above properties.

See also

• Finger tip unit
• Liniment
• Topical anesthetic
• Topical antibiotic
• Topical corticosteroids
• Unguent

References

• Goodman & Gilman's The Pharmacological Basis of Therapeutics
• Dr. David Edwards – Dentistry Microbiology Lecture series

1. "Psoriasis-Treatment". Medical Reference. University of Maryland Medical System. 2009. Archived from the original on 2013-05-20. Retrieved 2012-05-02.
2. ^ A.E. Benson, Heather; E. Grice, Jeffrey; Mohammed, Yousuf; Namjoshi, Sarika; S. Roberts, Michael (2019). "Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies". Current Drug Delivery. 16 (5): 440–460. doi:10.2174/1567201816666190201143457. PMC 6637104. PMID 30714524.
3. Singh, D.; Mital, N.; Kaur, G. (2016). "Topical Drug Delivery Systems: A Patent Review". Expert Opinion on Therapeutic Patents. 26 (2): 213–228. doi:10.1517/13543776.2016.1131267. PMID 26651499. S2CID 536499. Archived from the original on 15 June 2022. Retrieved 27 March 2021.
4. Holmgaard, R.; Nielsen, J.B. (2009). "Dermal absorption of pesticides – evaluation of variability and prevention" (PDF). Pesticides Research (124): 35–376. Archived (PDF) from the original on 2022-06-16. Retrieved 2022-09-28.
5. Yu, Yi-Qun; Yang, Xue; Wu, Xiao-Fang; Fan, Yi-Bin (2021-03-29). "Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications". Frontiers in Bioengineering and Biotechnology. 9. doi:10.3389/fbioe.2021.646554. ISSN 2296-4185. PMC 8039394. PMID 33855015.
6. "topical". Merriam-Webster dictionary. Archived from the original on 2017-07-30. Retrieved 2017-07-30.
7. thefreedictionary.com > topical Archived 2010-12-05 at the Wayback Machine Citing: The American Heritage Dictionary of the English Language, Fourth Edition, 2000
8. "topical". dictionary.com. Archived from the original on 2017-07-30. Retrieved 2017-07-30.
9. "Vancocin". The American Society of Health-System Pharmacists. Archived from the original on September 6, 2015. Retrieved Sep 4, 2015.
10. ^ Wolverton, SE. Comprehensive Dermatologic Drug Therapy. WB Saunders. 2001. pp 563–572.
11. ^ Wolverton, S. Comprehensive Dermatologic Drug Therapy. p. 13.
12. Habet, Kyle A; Kolli, Sree S; Pona, Adrian; Feldman, Steven R (2019). "A review of topical corticosteroid sprays for the treatment of inflammatory dermatoses". Dermatology Online Journal. 25 (8). doi:10.5070/d3258045123. ISSN 1087-2108. PMID 31553858.
13. ^ Maurya, Avanish; Gupta, Aditya; Maurya, Jayant Kumar (December 2023). "A Review Method And Types Of Ointment In Cosmecuticals" (PDF). International Journal of Novel Research and Development. 8 (12): 6 – via IJNRD.
14. "Doctor, why are you prescribing an ointment?" Archived 2019-12-15 at the Wayback Machine; American Academy of Dermatology
15. Singh Malik, D; Mital, N; Kaur, G (2016). "Topical drug delivery systems: a patent review". Expert Opinion on Therapeutic Patents. 26 (2): 213–228. doi:10.1517/13543776.2016.1131267. PMID 26651499. S2CID 536499.
16. Baranowski, P; Karolewicz, B; Gajda, M; Pluta, J (2014). "Ophthalmic drug dosage forms: characterisation and research methods". TheScientificWorldJournal. 2014: 861904. doi:10.1155/2014/861904. PMC 3977496. PMID 24772038.
17. Smith, KA; Rudmik, L (2016). Delivery of Topical Therapies. Advances in Oto-rhino-laryngology. Vol. 79. pp. 114–20. doi:10.1159/000445145. ISBN 978-3-318-05853-6. PMID 27466853.
18. Loyd Allen; Howard C. Ansel (2013). Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems (10th ed.). Lippincott Williams & Wilkins. p. 371. ISBN 978-1-4511-8876-9. Archived from the original on 2023-11-02. Retrieved 2020-05-09. Alt URL Archived 2021-11-04 at the Wayback Machine
19. PubChem. "Aluminum Acetate". pubchem.ncbi.nlm.nih.gov. Retrieved 2024-08-10.
20. Durani, Piyush; Leaper, David (June 2008). "Povidone–iodine: use in hand disinfection, skin preparation and antiseptic irrigation". International Wound Journal. 5 (3): 376–387. doi:10.1111/j.1742-481X.2007.00405.x. ISSN 1742-4801. PMC 7951395. PMID 18593388.
21. ^ Shah, Vinod P.; Yacobi, Avraham; Rădulescu, Flavian Ştefan; Miron, Dalia Simona; Lane, Majella E. (August 2015). "A science based approach to topical drug classification system (TCS)". International Journal of Pharmaceutics. 491 (1–2): 21–25. doi:10.1016/j.ijpharm.2015.06.011. PMID 26070249. Archived from the original on 2022-09-28. Retrieved 2022-09-28.
22. ^ Pastore, M. N.; Kalia, Y. N.; Horstmann, M.; Roberts, M. S. (2015). "Transdermal patches: history, development and pharmacology". British Journal of Pharmacology. 172 (9): 2179–2209. doi:10.1111/bph.13059. PMC 4403087. PMID 25560046.
23. Zhao, Lin; Chen, Jiamei; Bai, Bai; Song, Guili; Zhang, Jingwen; Yu, Han; Huang, Shiwei; Wang, Zhang; Lu, Guanghua (2024-01-16). "Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing". Frontiers in Pharmacology. 14. doi:10.3389/fphar.2023.1333986. ISSN 1663-9812. PMC 10825035. PMID 38293666.
24. ^ Florence, A. T., & Attwood, D. (2016). Physicochemical principles of pharmacy in manufacture, formulation and clinical use. London: (PhP) Pharmaceutical Press.

External links

• History of ointments

v t e Routes of administration, dosage forms
Oral	Digestive tract (enteral) Solids Tablet Capsule Pastille Time release technology Osmotic delivery system Liquids Decoction Elixir Electuary Emulsion Effervescent powder or tablet Herbal tea Hydrogel Molecular encapsulation Powder Softgel Solution Suspension Syrup Tincture Oral mucosa (buccal, sublabial, sublingual) Solids Orally disintegrating tablet Film Lollipop Sublingual drops Lozenges Effervescent tablet Chewing gum Liquids Mouthwash Toothpaste Ointment Spray Respiratory tract (inhalation) Solids Dry-powder inhaler Smoking 0 0 Liquids Anesthetic vaporizer Heated humidified high-flow therapy Medical inhalants Metered-dose inhaler (MDI) Nebulizer Vaporizer Gas Oxygen mask and Nasal cannula Oxygen concentrator Anaesthetic machine Medical inhalants Relative analgesia machine
Ophthalmic, otic, nasal	Nasal spray Ear drops Eye drops Ointment Hydrogel Insufflation Mucoadhesive microdisc
Urogenital	Ointment Pessary Vaginal ring Douche Intrauterine device (IUD) Extra-amniotic infusion Intravesical infusion
Rectal (enteral)	Ointment Suppository Enema Solution Hydrogel Murphy drip Nutrient enema
Dermal (topical)	Ointment Topical cream Topical gel Liniment Paste Film DMSO solution Iontophoresis Hydrogel Liposomes Transfersome vesicles Cream Lotion Lip balm Medicated shampoo Dermal patch Transdermal patch Transdermal spray Jet injector
Parenterals Injections infusions (into tissue/blood)	Skin (transdermal) Intradermal Subcutaneous Injector pen Transdermal implant Organs Intracavernous Intravitreal Intra-articular Central nervous system Intracerebral Intrathecal Epidural Circulatory, musculoskeletal Intravenous Intracardiac Intramuscular Intraosseous Intraperitoneal Nanocell injection Patient-controlled analgesia pump PIC line

• Medical terminology
• Routes of administration
• Ointments
• Drug delivery devices
• Dosage forms