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Tocofersolan

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Tocofersolan
Names
IUPAC name α-Hydro-ω-{-3,4-dihydro-2H-1-benzopyran-6-yl}oxy)butanoyl]oxy}poly(oxyethylene)
Other names Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate (TPGS); Liqui-E
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.123.651 Edit this at Wikidata
EC Number
  • 618-345-6
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3Key: AOBORMOPSGHCAX-UHFFFAOYSA-N
  • InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3Key: AOBORMOPSGHCAX-UHFFFAOYAU
SMILES
  • O=C(OCCO)CCC(=O)Oc2c(c(c1OC(CCc1c2C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)C
Properties
Chemical formula (C2H4O)nC33H54O5
Molar mass Variable
Pharmacology
ATC code A11HA08 (WHO)
License data
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound Pharmaceutical compound
Tocofersolan
Clinical data
Trade namesVedrop
Other namesTocophersolan (USAN US)
AHFS/Drugs.comUK Drug Information
Legal status
Legal status
  • UK: POM (Prescription only)
  • EU: Rx-only
Identifiers
DrugBank
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.123.651 Edit this at Wikidata

Tocofersolan (INN; also known as tocophersolan, tocopherol polyethylene glycol succinate, or TPGS) is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of α-tocopherol that enables water solubility.

Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease. On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients with congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).

Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.

References

  1. "Vedrop 50 mg/ml oral solution - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Retrieved 24 July 2020.
  2. "Vedrop EPAR". European Medicines Agency (EMA). Archived from the original on 24 July 2020. Retrieved 24 July 2020.
  3. "Tocophersolan Oral". WebMD.
  4. "Vedrop Summary of Product Characteristics" (PDF). European Medicines Agency.
  5. Ash M, Ash I (2004). Handbook of Preservatives. Synapse Info Resources. p. 568. ISBN 1-890595-66-7.
Vitamins (A11)
Fat
soluble
A
D
E
K
Water
soluble
B
C
Combinations
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