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TRPV3-74a

Identifiers
IUPAC name 3--1-methyl-3-cyclobutan-1-ol
CAS Number	1432051-63-2
PubChem CID	71554840
ChemSpider	58922619
ChEMBL	ChEMBL3828340
Chemical and physical data
Formula	C17H17F3N2O2
Molar mass	338.330 g·mol
3D model (JSmol)	Interactive image
SMILES C1(C((C2=CC=CC=N2)O)(C3=CC(C(F)(F)F)=CC=N3)C1)O
InChI InChI=1S/C17H17F3N2O2/c1-15(24)9-16(10-15,14(23)12-4-2-3-6-21-12)13-8-11(5-7-22-13)17(18,19)20/h2-8,14,23-24H,9-10H2,1H3/t14-,15?,16?/m1/s1 Key:MTJXDHFAWXGXIN-QQFBHYJXSA-N

TRPV3-74a is a drug which acts as a selective antagonist for the TRPV3 calcium channel. It has analgesic effects in animal studies against both neuropathic pain and normal pain responses.

References

1. Gomtsyan A, Schmidt RG, Bayburt EK, Gfesser GA, Voight EA, Daanen JF, et al. (May 2016). "Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists". Journal of Medicinal Chemistry. 59 (10): 4926–47. doi:10.1021/acs.jmedchem.6b00287. PMID 27077528.
2. Kocienski P (February 2017). "Synthesis of a TRPV3 Antagonist". Synfacts. 13 (2): 123. doi:10.1055/s-0036-1589889. S2CID 100058677.

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