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SN-2

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Chemical compound Pharmaceutical compound
SN-2
Identifiers
IUPAC name
  • 5-(2,4,6-trimethylphenyl)-3-oxa-4-azatricyclodec-4-ene
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H21NO
Molar mass255.361 g·mol
3D model (JSmol)
SMILES
  • CC1=CC(=C(C(=C1)C)C2=NOC3C2C4CCC3C4)C
InChI
  • InChI=1S/C17H21NO/c1-9-6-10(2)14(11(3)7-9)16-15-12-4-5-13(8-12)17(15)19-18-16/h6-7,12-13,15,17H,4-5,8H2,1-3H3
  • Key:WKLZNTYMDOPBSE-UHFFFAOYSA-N

SN-2 is a chemical compound which acts as an "agonist" (i.e. channel opener) for the TRPML3 calcium channel, with high selectivity for TRPML3 and no significant activity at the related TRPML1 and TRPML2 channels. It has demonstrated antiviral activity in an in vitro model.

See also

References

  1. Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, et al. (February 2010). "Small molecule activators of TRPML3". Chemistry & Biology. 17 (2): 135–48. doi:10.1016/j.chembiol.2009.12.016. PMC 2834294. PMID 20189104.
  2. Xia Z, Wang L, Li S, Tang W, Sun F, Wu Y, et al. (October 2020). "ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity". Antiviral Research. 182: 104922. doi:10.1016/j.antiviral.2020.104922. PMID 32858116. S2CID 221365410.
TRP channel modulators
TRPA
Activators
Blockers
TRPC
Activators
Blockers
TRPM
Activators
Blockers
TRPML
Activators
Blockers
TRPP
Activators
Blockers
TRPV
Activators
Blockers
See also: Receptor/signaling modulators • Ion channel modulators
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