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SB-366791

Identifiers
IUPAC name (E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide
CAS Number	472981-92-3
PubChem CID	667594
ChemSpider	580962
UNII	E8EY4M2N4H
ChEBI	CHEBI:93038
ChEMBL	ChEMBL122413
Chemical and physical data
Formula	C16H14ClNO2
Molar mass	287.74 g·mol
3D model (JSmol)	Interactive image
SMILES COC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(C=C2)Cl
InChI InChI=1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+ Key:RYAMDQKWNKKFHD-JXMROGBWSA-N

SB-366791 is a drug which acts as a potent and selective blocker of the TRPV1 ion channel. It has analgesic effects in animal studies, and is used in research into pain and inflammation.

See also

• AMG-517
• AMG-9810
• Discovery and development of TRPV1 antagonists

References

1. Dell H (December 2003). "New compound fires up pain research". Drug Discovery Today. 8 (23): 1053. doi:10.1016/s1359-6446(03)02928-3. PMID 14693457.
2. Ma SX, Kim HC, Lee SY, Jang CG (December 2018). "TRPV1 modulates morphine self-administration via activation of the CaMKII-CREB pathway in the nucleus accumbens". Neurochemistry International. 121: 1–7. doi:10.1016/j.neuint.2018.10.009. PMID 30292787. S2CID 52929149.
3. Uchytilova E, Spicarova D, Palecek J (April 2021). "Hypersensitivity Induced by Intrathecal Bradykinin Administration Is Enhanced by N-oleoyldopamine (OLDA) and Prevented by TRPV1 Antagonist". International Journal of Molecular Sciences. 22 (7): 3712. doi:10.3390/ijms22073712. PMC 8038144. PMID 33918267.

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• 4-Chlorophenyl compounds
• Amides
• 3-Methoxyphenyl compounds
• Transient receptor potential channel modulators
• Analgesic stubs