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OR6A2

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Protein-coding gene in the species Homo sapiens

OR6A2
Identifiers
AliasesOR6A2, I7, OR11-55, OR6A1, OR6A2P, olfactory receptor family 6 subfamily A member 2
External IDsOMIM: 608495; MGI: 97432; HomoloGene: 2743; GeneCards: OR6A2; OMA:OR6A2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)
Chromosome 11 (human)Genomic location for OR6A2Genomic location for OR6A2
Band11p15.4Start6,791,736 bp
End6,799,689 bp
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)
Chromosome 7 (mouse)Genomic location for OR6A2Genomic location for OR6A2
Band7|7 E3Start106,594,606 bp
End106,605,279 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle
Top expressed in
  • Jacobson's organ

  • secondary oocyte

  • yolk sac

  • peripheral nervous system

  • gastrula

  • vastus lateralis muscle

  • subdivision of respiratory system

  • respiratory epithelium

  • nasal epithelium

  • olfactory epithelium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8590

18317

Ensembl

ENSG00000184933

ENSMUSG00000070417

UniProt

O95222

n/a

RefSeq (mRNA)

NM_003696

NM_010983

RefSeq (protein)

NP_003687

n/a

Location (UCSC)Chr 11: 6.79 – 6.8 MbChr 7: 106.59 – 106.61 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene. It is Class II (tetrapod-specific) olfactory receptor and a rhodopsin-like receptor.

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals.

Clinical significance

Variation in the OR6A2 gene has been identified as a likely cause of why some people enjoy the smell and taste of coriander (also known as cilantro) while others are extremely repulsed by it. Depending on ancestry, between 3% and 21% of the population report disliking coriander: 21% for East Asians, 17% for Caucasians, 14% for those of African descent, 7% for South Asians, 4% for Hispanics, and 3% for Middle Eastern subjects. Some associate it with an intensely unpleasant taste, including a combination of soap and vomit, or say that it is similar to the foul smelling odor emitted by stinkbugs. This is suggested to be due to the presence of aldehyde chemicals, which may be present in soap, various detergents, coriander, and several species of stinkbugs.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000184933Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000070417Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2".
  6. Eriksson N, Wu S, Chuong BD, Kiefer AK, Tuing JY, Mountain JL, et al. (29 November 2012). "A genetic variant near olfactory receptor genes influences cilantro preference". Flavour. 1. arXiv:1209.2096. doi:10.1186/2044-7248-1-22. S2CID 199627.
  7. Mauer L, El-Sohemy A (2012-05-02). "Prevalence of cilantro (Coriandrum sativum) disliking among different ethnocultural groups". Flavour. 1 (1): 8. doi:10.1186/2044-7248-1-8. ISSN 2044-7248.
  8. Callaway E (September 2012). "Soapy taste of coriander linked to genetic variants". Nature. doi:10.1038/nature.2012.11398. S2CID 87980895.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


G protein-coupled receptors: olfactory receptors
Class I
(fish-like receptors)
Family 51
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Class II
(tetrapod specific receptors)
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