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Melitracen

Clinical data
Trade names	Adaptol, Dixeran, Melixeran, Thymeol, Trausabun
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral, intramuscular injection
ATC code	N06AA14 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 3-(10,10-dimethylanthracen-9(10H)-ylidene)-N,N-dimethylpropan-1-amine
CAS Number	5118-29-6
PubChem CID	25382
ChemSpider	23697
UNII	Q7T0Y1109Z
KEGG	D08171
ChEMBL	ChEMBL110094
CompTox Dashboard (EPA)	DTXSID4048274
ECHA InfoCard	100.023.507
Chemical and physical data
Formula	C21H25N
Molar mass	291.438 g·mol
3D model (JSmol)	Interactive image
SMILES c3ccc2c(/C(c1c(cccc1)C2(C)C)=C/CCN(C)C)c3
InChI InChI=1S/C21H25N/c1-21(2)19-13-7-5-10-17(19)16(12-9-15-22(3)4)18-11-6-8-14-20(18)21/h5-8,10-14H,9,15H2,1-4H3 Key:GWWLWDURRGNSRS-UHFFFAOYSA-N
(what is this?)  (verify)

Melitracen (brand names Melixeran, Trausabun) is a tricyclic antidepressant (TCA), for the treatment of depression and anxiety. In addition to single drug preparations, it is also available as Deanxit, marketed by Lundbeck, a combination product containing both melitracen and flupentixol.

The pharmacology of melitracen has not been properly investigated and is largely unknown, but it is likely to act in a similar manner to other TCAs. Indeed, melitracen is reported to have imipramine and amitriptyline-like effects and efficacy against depression and anxiety, though with improved tolerability and a somewhat faster onset of action.

See also

• Fluotracen
• Litracen
• Dimetacrine

References

1. Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
2. Rhodes PH (1996). Dictionary of organic compounds. London: Chapman & Hall. ISBN 0-412-54090-8.
3. O'Neil MJ (2001). The Merck index: an encyclopedia of chemicals, drugs, and biologicals. Rahway, NJ: Merck Research Laboratories. ISBN 0-911910-13-1.
4. Holenz J, Díaz JL, Buschmann H (2007). "Marketed Drugs and Drugs in DevelopmentVela". In JM, Buschmann H, Holenz J, Párraga A, Torrens A (eds.). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. ISBN 978-3-527-31058-6.
5. Muller NF, Dessing RP (1998). European Drug Index (4th ed.). Boca Raton: CRC Press. ISBN 3-7692-2114-1.
6. Van Moffaert M, Dierick M, De Meulemeester F, Vereecken A (1983). "Treatment of depressive anxiety states associated with psychosomatic symptoms. A double-blind multicentre clinical study: mianserin versus melitracen-flupentixol". Acta Psychiatrica Belgica. 83 (5): 525–539. PMID 6670581.
7. Bin Yaacob H (April 1985). "Flupenthixol and Melitracen in the management of trigeminal neuralgia". Dental Journal of Malaysia. 8 (2): 37–38. PMID 3917005.
8. Hashash JG, Abdul-Baki H, Azar C, Elhajj II, El Zahabi L, Chaar HF, Sharara AI (June 2008). "Clinical trial: a randomized controlled cross-over study of flupenthixol + melitracen in functional dyspepsia". Alimentary Pharmacology & Therapeutics. 27 (11): 1148–1155. doi:10.1111/j.1365-2036.2008.03677.x. PMID 18331614. S2CID 40714136.
9. Aronson JK (2008). Meyler's Side Effects of Psychiatric Drugs (Meylers Side Effects). Amsterdam: Elsevier Science. ISBN 978-0-444-53266-4.
10. Krapcho J (1970). "Antidepressives and Stimulants". Annual Reports in Medicinal Chemistry. Vol. 5. Boston: Academic Press. ISBN 0-12-040505-9.

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