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KCNH4

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Protein-coding gene in the species Homo sapiens
KCNH4
Identifiers
AliasesKCNH4, BEC2, ELK1, Kv12.3, potassium voltage-gated channel subfamily H member 4
External IDsOMIM: 604528; MGI: 2156184; HomoloGene: 8180; GeneCards: KCNH4; OMA:KCNH4 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)
Chromosome 17 (human)Genomic location for KCNH4Genomic location for KCNH4
Band17q21.2Start42,156,891 bp
End42,181,142 bp
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)
Chromosome 11 (mouse)Genomic location for KCNH4Genomic location for KCNH4
Band11 D|11 63.57 cMStart100,631,202 bp
End100,650,768 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • putamen

  • testicle

  • caudate nucleus

  • nucleus accumbens

  • prefrontal cortex

  • right frontal lobe

  • Brodmann area 9

  • primary visual cortex

  • anterior cingulate cortex

  • appendix
Top expressed in
  • striatum of neuraxis

  • superior frontal gyrus

  • primary visual cortex

  • Mesencephalon

  • olfactory bulb

  • neural tube

  • epiblast

  • ganglionic eminence

  • Hypothalamus

  • rhombencephalon
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23415

380728

Ensembl

ENSG00000089558

ENSMUSG00000035355

UniProt

Q9UQ05

A2A5F7

RefSeq (mRNA)

NM_012285

NM_001081194

RefSeq (protein)

NP_036417

NP_001074663

Location (UCSC)Chr 17: 42.16 – 42.18 MbChr 11: 100.63 – 100.65 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Potassium voltage-gated channel subfamily H member 4 is a protein, that in humans, is encoded by the KCNH4 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000089558Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000035355Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miyake A, Mochizuki S, Yokoi H, Kohda M, Furuichi K (Sep 1999). "New ether-a-go-go K(+) channel family members localized in human telencephalon". J Biol Chem. 274 (35): 25018–25. doi:10.1074/jbc.274.35.25018. PMID 10455180.
  6. ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

Further reading

External links

Membrane transport protein: ion channels (TC 1A)
Ca: Calcium channel
Ligand-gated
Voltage-gated
Na: Sodium channel
Constitutively active
Proton-gated
Voltage-gated
K: Potassium channel
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl: Chloride channel
H: Proton channel
M: CNG cation channel
M: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders


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