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GJB7
Identifiers
Aliases	GJB7, CX25, bA136M9.1, connexin25, gap junction protein beta 7
External IDs	OMIM: 611921; HomoloGene: 89311; GeneCards: GJB7; OMA:GJB7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q14.3-q15 Start 87,282,980 bp End 87,329,278 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad right uterine tube testicle placenta Pituitary Gland anterior pituitary olfactory zone of nasal mucosa right lung bone marrow mucosa of transverse colon n/a More reference expression data BioGPS n/a
Gene ontology Molecular function gap junction channel activity Cellular component integral component of membrane gap junction cell junction plasma membrane connexin complex membrane Biological process cell communication transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 375519 n/a Ensembl ENSG00000164411 n/a UniProt Q6PEY0 n/a RefSeq (mRNA) NM_198568 n/a RefSeq (protein) NP_940970 n/a Location (UCSC) Chr 6: 87.28 – 87.33 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Gap junction beta-7 protein (GJB7), also known as connexin-25 (Cx25), is a protein that in humans is encoded by the GJB7 gene.

Function

Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000164411 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ "Entrez Gene: gap junction protein".
4. Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. S2CID 225894.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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• Connexins