Cinoxate - Misplaced Pages

UV filter used in sunscreens

Cinoxate
Names


Preferred IUPAC name 2-Ethoxyethyl (2E)-3-(4-methoxyphenyl)prop-2-enoate
Other names 2-Ethoxyethyl p-methoxycinnamate
Identifiers
CAS Number	104-28-9
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL2104045
ChemSpider	4523729
ECHA InfoCard	100.002.901
KEGG	D03512
PubChem CID	5373773
UNII	5437O7N5BH
CompTox Dashboard (EPA)	DTXSID101167513 DTXSID2025264, DTXSID101167513
InChI InChI=1S/C14H18O4/c1-3-17-10-11-18-14(15)9-6-12-4-7-13(16-2)8-5-12/h4-9H,3,10-11H2,1-2H3/b9-6+Key: CMDKPGRTAQVGFQ-RMKNXTFCSA-N InChI=1/C14H18O4/c1-3-17-10-11-18-14(15)9-6-12-4-7-13(16-2)8-5-12/h4-9H,3,10-11H2,1-2H3/b9-6+Key: CMDKPGRTAQVGFQ-RMKNXTFCBV
SMILES O=C(OCCOCC)\C=C\c1ccc(OC)cc1
Properties
Chemical formula	C₁₄H₁₈O₄
Molar mass	250.294 g·mol
Density	1.102 g/cm
Melting point	−25 °C (−13 °F; 248 K)
Boiling point	184 to 187 °C (363 to 369 °F; 457 to 460 K) at 2 mmHg
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is ?) Infobox references

Chemical compound

Cinoxate is an organic compound used as an ingredient in some types of sunscreens. It is an ester formed from methoxycinnamic acid and 2-ethoxyethanol. It is a slightly yellow viscous liquid that is insoluble in water, but miscible with alcohols, esters, and vegetable oils.

It was approved as UV filter in the USA by the FDA in 1961, but it is not commonly used in cosmetic formulations anymore.

References

Merck Index, 11th Edition, 2312.
Pantelic, Molly N.; Wong, Nikita; Kwa, Michael; Lim, Henry W. (24 February 2023). "Ultraviolet filters in the United States and European Union: A review of safety and implications for the future of US sunscreens". Journal of the American Academy of Dermatology. 88 (3): 632–646. doi:10.1016/j.jaad.2022.11.039. PMID 36442641.

v t e Sunscreening agents approved by the US FDA or other agencies
UVA: 400–315 nm UVB: 315–290 nm Chemical agents unless otherwise noted
UVA filters	Avobenzone (Parsol 1789) Bisdisulizole disodium (Neo Heliopan AP) Diethylamino hydroxybenzoyl hexyl benzoate (Uvinul A Plus) Ecamsule (Mexoryl SX) Menthyl anthranilate
UVB filters	Amiloxate 4-Aminobenzoic acid (PABA) Cinoxate Ethylhexyl triazone (Uvinul T 150) Homosalate 4-Methylbenzylidene camphor (Enzacamene) Octyl methoxycinnamate (Octinoxate) Octyl salicylate (Octisalate) Padimate O (Escalol 507) Phenylbenzimidazole sulfonic acid (Ensulizole) Polysilicone-15 (Parsol SLX) Trolamine salicylate
UVA+UVB filters	Bemotrizinol (Tinosorb S) Benzophenones 1–12 Dioxybenzone Drometrizole trisiloxane (Mexoryl XL) Iscotrizinol (Uvasorb HEB) Octocrylene Oxybenzone (Eusolex 4360) Sulisobenzone Hybrid (chemical/physical): Bisoctrizole (Tinosorb M / Eversorb M) Physical: Titanium dioxide Zinc oxide
See also: Photoprotection, Sun protective clothing, Sun tanning, and Sunburn

This article about an ester is a stub. You can help Misplaced Pages by expanding it.