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CLCC1

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Protein-coding gene in the species Homo sapiens
CLCC1
Identifiers
AliasesCLCC1, MCLC, chloride channel CLIC like 1
External IDsOMIM: 617539; MGI: 2385186; HomoloGene: 9032; GeneCards: CLCC1; OMA:CLCC1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for CLCC1Genomic location for CLCC1
Band1p13.3Start108,929,508 bp
End108,963,457 bp
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)
Chromosome 3 (mouse)Genomic location for CLCC1Genomic location for CLCC1
Band3|3 F3Start108,561,229 bp
End108,586,156 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • buccal mucosa cell

  • Achilles tendon

  • internal globus pallidus

  • stromal cell of endometrium

  • body of pancreas

  • islet of Langerhans

  • gastrocnemius muscle

  • epithelium of colon

  • corpus callosum
Top expressed in
  • spermatocyte

  • seminal vesicula

  • intercostal muscle

  • primary oocyte

  • right kidney

  • parotid gland

  • lobe of cerebellum

  • median eminence

  • Gonadal ridge

  • muscle of thigh
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23155

229725

Ensembl

ENSG00000121940

ENSMUSG00000027884

UniProt

Q96S66

Q99LI2

RefSeq (mRNA)

NM_015127
NM_001048210
NM_001278202
NM_001278203

NM_001177770
NM_001177771
NM_145543
NM_001355632

RefSeq (protein)
NP_001041675
NP_001265131
NP_001265132
NP_055942
NP_001364387

NP_001364388
NP_001364389
NP_001364390
NP_001364391
NP_001364392
NP_001364393
NP_001364394
NP_001364395
NP_001364396
NP_001364397
NP_001364398
NP_001364399

NP_001171241
NP_001171242
NP_663518
NP_001342561

Location (UCSC)Chr 1: 108.93 – 108.96 MbChr 3: 108.56 – 108.59 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Chloride channel CLIC-like 1 also known as CLCC1 is a human gene.

The protein encoded by this gene is a chloride channel which is related in sequence to the S. cerevisiae MID-1 stretch-activated channel. CLCC1 is located in the membranes of intracellular compartments including endoplasmic reticulum and the Golgi apparatus. It is highly expressed in the testis and moderately in the spleen, liver, kidney, heart, brain, and lung.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000121940Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000027884Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. ^ Nagasawa M, Kanzaki M, Iino Y, Morishita Y, Kojima I (June 2001). "Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus". J. Biol. Chem. 276 (23): 20413–8. doi:10.1074/jbc.M100366200. PMID 11279057.

Further reading

External links

Membrane transport protein: ion channels (TC 1A)
Ca: Calcium channel
Ligand-gated
Voltage-gated
Na: Sodium channel
Constitutively active
Proton-gated
Voltage-gated
K: Potassium channel
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl: Chloride channel
H: Proton channel
M: CNG cation channel
M: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders


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