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CFU-GM
Lineage. Captions in Polish, but "GMP" visible near bottom center.
Details
Gives rise to	Monoblasts and myeloblasts
Location	Bone marrow
Function	colony forming unit
Identifiers
MeSH	D055014
TH	H2.00.04.3.02009
Anatomical terms of microanatomy[edit on Wikidata]

CFU-GM (Colony Forming Unit–Granulocyte–Macrophage), also known as granulocyte–macrophage progenitor (GMP), is a colony forming unit. It is derived from CFU-GEMM. It is the precursor for monoblasts and myeloblasts. Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).

Granulocytes

There is some controversy over which granulocytes derive from CFU-GM.

• There is little disagreement that neutrophils come from CFU-GM.
• Some sources state that basophils also derive from CFU-GM, but that eosinophils come from "CFU-Eos".
• Other sources state that basophils do not derive from CFU-GM, but from a distinct CFU, titled "CFU-Baso".

See also

• Hematopoietic stem cell § Nomenclature of hematopoietic colonies and lineages

Notes

1. The "GM" can also stand for "Granulocyte-Monocyte".

References

1. "Hem I WBC Morphology and Physiology". Archived from the original on December 25, 2008. Retrieved 2008-12-30.
2. Ganong, William F.; McPhee, Stephen J.; Lingappa, Vishwanath R. (2005). Pathophysiology of Disease: An Introduction to Clinical Medicine (Lange). McGraw-Hill Medical. p. 107. ISBN 0-07-144159-X.
3. Rudolph, Colin David (2003). Rudolph's pediatrics. New York: McGraw-Hill, Medical Pub. Division. p. 1563. ISBN 0-8385-8285-0.

External links

• CFU-GM at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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