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Anisodamine

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Chemical compound Pharmaceutical compound
Anisodamine
Clinical data
Other names7β-hydroxyhyoscyamine
ATC code
  • None
Identifiers
IUPAC name
  • octan-3-yl] (2S)-3-hydroxy-2-phenyl-propanoate
CAS Number
PubChem CID
ChemSpider
UNII
ECHA InfoCard100.164.962 Edit this at Wikidata
Chemical and physical data
FormulaC17H23NO4
Molar mass305.374 g·mol
3D model (JSmol)
SMILES
  • O=C(O1C2N(C)(C1)C2O)(c3ccccc3)CO
InChI
  • InChI=1S/C17H23NO4/c1-18-12-7-13(9-15(18)16(20)8-12)22-17(21)14(10-19)11-5-3-2-4-6-11/h2-6,12-16,19-20H,7-10H2,1H3/t12-,13+,14-,15+,16+/m1/s1
  • Key:WTQYWNWRJNXDEG-LEOABGAYSA-N
  (verify)

Anisodamine, also known as 7β-hydroxyhyoscyamine, is an anticholinergic and α1 adrenergic receptor antagonist used in the treatment of acute circulatory shock in China. It is given orally or by injection, as a racemic mixture (racanisodamine) or as a hydrobromide salt. Eye drops at 0.5% concentration for slowing the progression of myopia is also available in China.

Anisodamine is a naturally occurring tropane alkaloid found in some plants of the family Solanaceae including Datura. Its Mandarin Chinese name 山莨菪碱 is given after Anisodus tanguticus (Chinese: 山莨菪; pinyin: shān làng dàng).

See also

References

  1. Varma DR, Yue TL (March 1986). "Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats". British Journal of Pharmacology. 87 (3): 587–94. doi:10.1111/j.1476-5381.1986.tb10201.x. PMC 1916562. PMID 2879586.
  2. "Pharmacopoeia Search: "山莨菪碱"". 中国药典. Archived from the original on 2017-12-03.
  3. "消旋山莨菪碱滴眼液防治少年儿童假性近视的疗效分析". 国际医药卫生导报 (in Chinese (China)). 14 (15): 67–68. 2008. doi:10.3760/cma.j.issn.1007-1245.2008.15.027. Archived from the original on 2023-03-27. Retrieved 2017-12-03.
  4. Ye N, Li J, Gao C, Xie Y (August 2013). "Simultaneous determination of atropine, scopolamine, and anisodamine in Flos daturae by capillary electrophoresis using a capillary coated by graphene oxide". Journal of Separation Science. 36 (16): 2698–702. doi:10.1002/jssc.201300304. PMID 23868645.
  5. Zhang WW, Song MK, Cui YY, et al. (October 2008). "Differential neuropsychopharmacological influences of naturally occurring tropane alkaloids anisodamine versus scopolamine". Neuroscience Letters. 443 (3): 241–5. doi:10.1016/j.neulet.2008.07.048. PMID 18672024. S2CID 2730169.
  6. "消旋山莨菪碱" (in Chinese (China)). 中国药典. Archived from the original on 2017-12-03. Retrieved 3 December 2017.
Adrenergic receptor modulators
α1
Agonists
Antagonists
α2
Agonists
Antagonists
β
Agonists
Antagonists
Muscarinic acetylcholine receptor modulators
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Nicotinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators


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