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Allithiamine

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Chemical compound Pharmaceutical compound
Allithiamine
Skeletal formula of allithiamine
Ball-and-stick model of the allithiamine molecule
Clinical data
ATC code
  • None
Identifiers
IUPAC name
  • N--N-formamide
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC15H22N4O2S2
Molar mass354.49 g·mol
3D model (JSmol)
SMILES
  • O=CN(/C(=C(\SSC\C=C)CCO)C)Cc1cnc(nc1N)C
InChI
  • InChI=1S/C15H22N4O2S2/c1-4-7-22-23-14(5-6-20)11(2)19(10-21)9-13-8-17-12(3)18-15(13)16/h4,8,10,20H,1,5-7,9H2,2-3H3,(H2,16,17,18)/b14-11-
  • Key:WNCAVNGLACHSRZ-KAMYIIQDSA-N
  (what is this?)  (verify)

Allithiamine (thiamine allyl disulfide or TAD) is a lipid-soluble form of vitamin B1 which was discovered in garlic (Allium sativum) in the 1950s along with its homolog prosultiamine. They were both investigated for their ability to treat Wernicke–Korsakoff syndrome and beriberi better than thiamine.

See also

References

  1. Fujiwara M, Watanabe H, Matsui K (1954). ""Allithiamine" A Newly Found Derivative of Vitamin B1". The Journal of Biochemistry. 41: 29–39. doi:10.1093/oxfordjournals.jbchem.a126421.
  2. Rogers EF (April 1962). "Thiamine antagonists". Annals of the New York Academy of Sciences. 98 (2): 412–429. Bibcode:1962NYASA..98..412R. doi:10.1111/j.1749-6632.1962.tb30563.x. PMID 14493332. S2CID 32281714.
Vitamins (A11)
Fat
soluble
A
D
E
K
Water
soluble
B
C
Combinations
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