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AM-0902

Identifiers
IUPAC name 1-({3--1,2,4-oxadiazol-5-yl}methyl)-7-methylpurin-6-one
CAS Number	1883711-97-4
PubChem CID	73297271
ChemSpider	58864849
UNII	3E4SQ96PCJ
ChEMBL	ChEMBL3785736
Chemical and physical data
Formula	C17H15ClN6O2
Molar mass	370.80 g·mol
3D model (JSmol)	Interactive image
SMILES CN1C=NC2=C1C(=O)N(C=N2)CC3=NC(=NO3)CCC4=CC=C(C=C4)Cl
InChI InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3 Key:AWJBWNUUODWOKQ-UHFFFAOYSA-N

AM-0902 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, and has analgesic and antiinflammatory effects.

References

1. Schenkel LB, Olivieri PR, Boezio AA, Deak HL, Emkey R, Graceffa RF, et al. (March 2016). "Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity". Journal of Medicinal Chemistry. 59 (6): 2794–809. doi:10.1021/acs.jmedchem.6b00039. PMID 26942860.
2. Huang Y, Chen SR, Chen H, Pan HL (May 2019). "Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain". Journal of Neurochemistry. 149 (3): 381–398. doi:10.1111/jnc.14677. PMC 6483867. PMID 30716174.

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